/* Layout: editorial lab journal. Porcelain page, ink type, a "sequencing track" motif
   (bands like a gel / karyogram) as the brand signature. Category hue drives each post. */
:root {
  --paper: #F3F5F3;
  --surface: #FFFFFF;
  --ink: #0F1C1D;
  --muted: #52605F;
  --line: #D7DEDB;
  --gold: #A67C2E;
  --accent: #0F6E68;
  --cat: var(--accent);
  --c-a: #0F6E68; --c-c: #A67C2E; --c-g: #3E4FA8; --c-t: #A2512E;
  --shadow: 0 1px 2px rgba(15,28,29,.06), 0 12px 32px -12px rgba(15,28,29,.18);
  --f-display: "Bodoni Moda", "Didot", "Bodoni 72", Georgia, serif;
  --f-body: "Public Sans", "Segoe UI", system-ui, sans-serif;
  --f-mono: "JetBrains Mono", ui-monospace, "Cascadia Mono", Consolas, monospace;
  --w: 1180px;
  --measure: 68ch;
  color-scheme: light;
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --paper: #0B1313; --surface: #121D1D; --ink: #E4ECEA; --muted: #9AAAA7;
    --line: #243333; --gold: #D2A65A; --accent: #4FC2B8;
    --shadow: 0 1px 2px rgba(0,0,0,.4), 0 16px 40px -16px rgba(0,0,0,.7);
    color-scheme: dark;
  }
}
:root[data-theme="dark"] {
  --paper: #0B1313; --surface: #121D1D; --ink: #E4ECEA; --muted: #9AAAA7;
  --line: #243333; --gold: #D2A65A; --accent: #4FC2B8;
  --shadow: 0 1px 2px rgba(0,0,0,.4), 0 16px 40px -16px rgba(0,0,0,.7);
  color-scheme: dark;
}

*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; scroll-behavior: smooth; }
body {
  margin: 0; background: var(--paper); color: var(--ink);
  font: 400 1.0625rem/1.65 var(--f-body);
  -webkit-font-smoothing: antialiased;
}
img, svg { max-width: 100%; }
a { color: inherit; }
:focus-visible { outline: 2px solid var(--gold); outline-offset: 3px; border-radius: 4px; }
.wrap {
  max-width: var(--w); margin-inline: auto;
  padding-left: max(20px, env(safe-area-inset-left, 0px));
  padding-right: max(20px, env(safe-area-inset-right, 0px));
}
.eyebrow {
  font: 500 .72rem/1 var(--f-mono); letter-spacing: .14em; text-transform: uppercase; color: var(--muted);
}
h1, h2, h3 { font-family: var(--f-display); font-weight: 600; line-height: 1.08; text-wrap: balance; margin: 0; }

/* ---------- header ---------- */
.site-head {
  position: sticky; top: 0; z-index: 20;
  background: color-mix(in srgb, var(--paper) 86%, transparent);
  backdrop-filter: saturate(1.4) blur(12px); -webkit-backdrop-filter: saturate(1.4) blur(12px);
  border-bottom: 1px solid var(--line);
}
.site-head .wrap { display: flex; align-items: center; gap: 24px; height: 68px; }
.brand { display: flex; align-items: center; gap: 12px; text-decoration: none; }
.brand-mark { width: 30px; height: 30px; flex: none; }
.brand-name { font: 600 1.5rem/1 var(--f-display); letter-spacing: -.01em; }
.brand-by { font: 500 .62rem/1.2 var(--f-mono); letter-spacing: .16em; text-transform: uppercase; color: var(--muted); display: block; margin-top: 3px; }
.nav { margin-left: auto; display: flex; align-items: center; gap: 4px; }
.nav a { text-decoration: none; font-size: .9rem; color: var(--muted); padding: 8px 12px; border-radius: 999px; }
.nav a:hover, .nav a[aria-current="page"] { color: var(--ink); background: var(--surface); }
.theme-btn {
  border: 1px solid var(--line); background: var(--surface); color: var(--ink);
  width: 38px; height: 38px; border-radius: 50%; display: grid; place-items: center; cursor: pointer;
}
@media (max-width: 720px) { .nav a.hide-sm { display: none; } .brand-by { display: none; } }

/* ---------- hero ---------- */
.hero { padding-block: clamp(48px, 8vw, 96px) 40px; position: relative; }
.hero-grid { display: grid; grid-template-columns: 1.15fr .85fr; gap: clamp(28px, 5vw, 64px); align-items: end; }
.hero h1 { font-size: clamp(2.6rem, 6.4vw, 5.4rem); letter-spacing: -.025em; font-weight: 500; }
.hero h1 em { font-style: italic; color: var(--gold); }
.hero p.lede { font-size: clamp(1.05rem, 1.6vw, 1.25rem); color: var(--muted); max-width: 46ch; margin: 22px 0 0; }
.hero-cta { display: flex; flex-wrap: wrap; gap: 12px; margin-top: 30px; }
.btn {
  display: inline-flex; align-items: center; gap: 10px; text-decoration: none; cursor: pointer;
  font: 600 .92rem/1 var(--f-body); padding: 14px 20px; border-radius: 999px; border: 1px solid var(--ink);
  background: var(--ink); color: var(--paper); transition: transform .2s ease;
}
.btn:hover { transform: translateY(-1px); }
.btn.ghost { background: transparent; color: var(--ink); border-color: var(--line); }
.specimen {
  background: var(--surface); border: 1px solid var(--line); border-radius: 18px; padding: 20px; box-shadow: var(--shadow);
  min-width: 0;
}
.specimen-head { display: flex; justify-content: space-between; gap: 12px; }
.specimen canvas { display: block; width: 100%; height: 150px; margin-block: 16px 14px; }
.specimen dl { display: grid; grid-template-columns: repeat(3, 1fr); gap: 12px; margin: 0; border-top: 1px solid var(--line); padding-top: 14px; }
.specimen dt { font: 500 .62rem/1.3 var(--f-mono); letter-spacing: .1em; text-transform: uppercase; color: var(--muted); }
.specimen dd { margin: 4px 0 0; font: 500 1.35rem/1.1 var(--f-display); font-variant-numeric: tabular-nums; }
.seq { font: 500 .78rem/1.5 var(--f-mono); color: var(--muted); white-space: nowrap; overflow: hidden; letter-spacing: .12em; }
.seq b { color: var(--accent); font-weight: 600; }

/* ---------- trust bar ---------- */
.trust { border-block: 1px solid var(--line); }
.trust .wrap { display: grid; grid-template-columns: repeat(4, 1fr); gap: 0; }
.trust div { padding: 22px 20px 22px 0; display: flex; flex-direction: column; gap: 6px; }
.trust div + div { padding-left: 20px; border-left: 1px solid var(--line); }
.trust strong { font: 600 .95rem/1.3 var(--f-body); }
.trust span { font-size: .85rem; color: var(--muted); }

/* ---------- filters + grid ---------- */
.section { padding-block: 64px; }
.section-head { display: flex; flex-wrap: wrap; align-items: end; justify-content: space-between; gap: 18px; margin-bottom: 28px; }
.section-head h2 { font-size: clamp(1.8rem, 3.4vw, 2.6rem); font-weight: 500; }
.chips { display: flex; flex-wrap: wrap; gap: 8px; }
.chip {
  font: 500 .85rem/1 var(--f-body); padding: 10px 14px; border-radius: 999px; cursor: pointer;
  border: 1px solid var(--line); background: var(--surface); color: var(--ink);
  display: inline-flex; align-items: center; gap: 8px; text-decoration: none;
}
.chip i { width: 8px; height: 8px; border-radius: 50%; background: var(--c, var(--ink)); }
.chip[aria-pressed="true"] { background: var(--ink); color: var(--paper); border-color: var(--ink); }

.featured {
  display: grid; grid-template-columns: 1.2fr 1fr; background: var(--surface); border: 1px solid var(--line);
  border-radius: 22px; overflow: hidden; text-decoration: none; box-shadow: var(--shadow); margin-bottom: 28px;
}
.featured .cover { aspect-ratio: auto; min-height: 340px; }
.featured .body { padding: clamp(24px, 4vw, 44px); display: flex; flex-direction: column; gap: 16px; justify-content: center; min-width: 0; }
.featured h3 { font-size: clamp(1.7rem, 3vw, 2.5rem); font-weight: 500; }
.featured p { color: var(--muted); margin: 0; }

.grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 22px; }
.card {
  display: flex; flex-direction: column; text-decoration: none; border-radius: 18px; overflow: hidden;
  background: var(--surface); border: 1px solid var(--line); transition: transform .25s ease, box-shadow .25s ease;
}
.card:hover { transform: translateY(-3px); box-shadow: var(--shadow); }
.card .cover { aspect-ratio: 16/9; }
.card .body { padding: 20px 22px 24px; display: flex; flex-direction: column; gap: 10px; flex: 1; min-width: 0; }
.card h3 { font-size: 1.4rem; font-weight: 500; }
.card p { color: var(--muted); font-size: .95rem; margin: 0; }
.meta { display: flex; flex-wrap: wrap; align-items: center; gap: 10px; font: 500 .72rem/1 var(--f-mono); letter-spacing: .08em; text-transform: uppercase; color: var(--muted); }
.meta .cat { color: var(--cat); display: inline-flex; align-items: center; gap: 6px; }
.meta .cat::before { content: ""; width: 7px; height: 7px; border-radius: 50%; background: var(--cat); }
.meta .lvl { border: 1px solid var(--line); padding: 4px 7px; border-radius: 6px; }
.card .meta.bottom { margin-top: auto; padding-top: 8px; }
.cover { display: block; width: 100%; background: var(--ink); }
.cover svg { display: block; width: 100%; height: 100%; }
.empty { color: var(--muted); padding: 30px 0; }

/* ---------- tracks (study paths) ---------- */
.tracks { display: grid; grid-template-columns: repeat(5, 1fr); gap: 14px; }
.track {
  border-top: 3px solid var(--cat); background: var(--surface); border-radius: 0 0 14px 14px; padding: 18px;
  display: flex; flex-direction: column; gap: 8px; text-decoration: none; border-inline: 1px solid var(--line); border-bottom: 1px solid var(--line);
}
.track h3 { font-size: 1.25rem; font-weight: 500; }
.track p { margin: 0; font-size: .88rem; color: var(--muted); }
.track .count { font: 500 .72rem/1 var(--f-mono); color: var(--cat); margin-top: auto; padding-top: 8px; letter-spacing: .06em; }

/* ---------- newsletter ---------- */
.signup { background: var(--ink); color: var(--paper); border-radius: 26px; padding: clamp(28px, 5vw, 56px); display: grid; grid-template-columns: 1.1fr 1fr; gap: 32px; align-items: center; position: relative; overflow: hidden; }
.signup h2 { font-size: clamp(1.8rem, 3.6vw, 2.8rem); font-weight: 500; }
.signup p { color: color-mix(in srgb, var(--paper) 72%, transparent); margin: 12px 0 0; }
.signup form { display: flex; gap: 10px; flex-wrap: wrap; }
.signup input {
  flex: 1 1 220px; min-width: 0; font: inherit; padding: 14px 18px; border-radius: 999px; border: 1px solid color-mix(in srgb, var(--paper) 25%, transparent);
  background: transparent; color: var(--paper);
}
.signup input::placeholder { color: color-mix(in srgb, var(--paper) 55%, transparent); }
.signup .btn { background: var(--gold); border-color: var(--gold); color: #1A1407; }
.signup .note { font-size: .8rem; flex-basis: 100%; margin: 4px 0 0; }

/* ---------- footer ---------- */
.site-foot { border-top: 1px solid var(--line); margin-top: 72px; padding-block: 40px; color: var(--muted); font-size: .9rem; }
.site-foot .wrap { display: flex; flex-wrap: wrap; justify-content: space-between; gap: 20px; }
.site-foot a { text-decoration: none; }
.site-foot a:hover { color: var(--ink); }
.foot-links { display: flex; gap: 18px; flex-wrap: wrap; }

/* ---------- article ---------- */
.progress { position: fixed; top: 0; left: 0; height: 3px; width: 0; background: var(--cat); z-index: 30; }
.post-hero { padding-block: 56px 32px; }
.post-hero .wrap { display: grid; gap: 22px; max-width: 920px; }
.post-hero h1 { font-size: clamp(2.3rem, 5.4vw, 4.2rem); font-weight: 500; letter-spacing: -.02em; }
.post-hero .dek { font-size: clamp(1.1rem, 1.8vw, 1.3rem); color: var(--muted); max-width: 60ch; margin: 0; }
.byline { display: flex; align-items: center; gap: 12px; font-size: .9rem; color: var(--muted); }
.byline .avatar { width: 40px; height: 40px; border-radius: 50%; background: var(--ink); display: grid; place-items: center; }
.byline strong { color: var(--ink); display: block; font-weight: 600; }
.post-cover { max-width: var(--w); margin-inline: auto; padding-inline: max(20px, env(safe-area-inset-left, 0px)) max(20px, env(safe-area-inset-right, 0px)); }
.post-cover .cover { aspect-ratio: 21/8; border-radius: 22px; overflow: hidden; }
.post-layout { display: grid; grid-template-columns: 220px minmax(0, 1fr); gap: 56px; padding-block: 48px; }
.toc { position: sticky; top: 100px; align-self: start; font-size: .88rem; }
.toc ol { list-style: none; padding: 0; margin: 12px 0 0; display: grid; gap: 2px; border-left: 1px solid var(--line); }
.toc a { display: block; text-decoration: none; color: var(--muted); padding: 6px 0 6px 14px; margin-left: -1px; border-left: 2px solid transparent; }
.toc a.on { color: var(--ink); border-left-color: var(--cat); }
.prose { max-width: var(--measure); min-width: 0; }
.prose > * + * { margin-top: 1.1em; }
.prose h2 { font-size: clamp(1.6rem, 2.8vw, 2.1rem); font-weight: 500; margin-top: 2.2em; scroll-margin-top: 90px; }
.prose h3 { font-size: 1.3rem; font-weight: 600; margin-top: 1.8em; }
.prose p, .prose li { color: color-mix(in srgb, var(--ink) 88%, var(--paper)); }
.prose ul, .prose ol { padding-left: 1.3em; }
.prose li + li { margin-top: .4em; }
.prose a { color: var(--cat); text-underline-offset: 3px; }
.prose code { font: .88em var(--f-mono); background: var(--surface); border: 1px solid var(--line); padding: 1px 6px; border-radius: 5px; }
.prose blockquote { margin-inline: 0; padding: 4px 0 4px 22px; border-left: 2px solid var(--gold); font: italic 400 1.3rem/1.45 var(--f-display); }
.prose .table { overflow-x: auto; border: 1px solid var(--line); border-radius: 14px; background: var(--surface); }
.prose table { border-collapse: collapse; width: 100%; font-size: .92rem; font-variant-numeric: tabular-nums; }
.prose th, .prose td { text-align: left; padding: 11px 14px; border-bottom: 1px solid var(--line); vertical-align: top; }
.prose th { font: 500 .7rem/1.3 var(--f-mono); letter-spacing: .1em; text-transform: uppercase; color: var(--muted); }
.prose tr:last-child td { border-bottom: 0; }
.callout { border-radius: 16px; padding: 20px 22px; background: color-mix(in srgb, var(--cat) 9%, var(--surface)); border: 1px solid color-mix(in srgb, var(--cat) 28%, var(--line)); }
.callout .eyebrow { color: var(--cat); display: block; margin-bottom: 10px; }
.callout > *:last-child { margin-bottom: 0; }
.callout ul { margin: 0; }
.callout.estudo { background: var(--surface); border-color: var(--line); }
.refs { font-size: .9rem; }
.refs li { color: var(--muted); }
.author-box { margin-top: 56px; border-top: 1px solid var(--line); padding-top: 28px; display: flex; gap: 16px; align-items: flex-start; }
.author-box p { margin: 4px 0 0; color: var(--muted); font-size: .93rem; }
.related { border-top: 1px solid var(--line); }
@media (max-width: 960px) {
  .hero-grid, .featured, .signup { grid-template-columns: 1fr; }
  .grid { grid-template-columns: repeat(2, 1fr); }
  .tracks { grid-template-columns: repeat(2, 1fr); }
  .trust .wrap { grid-template-columns: repeat(2, 1fr); }
  .trust div:nth-child(3) { padding-left: 0; border-left: 0; }
  .post-layout { grid-template-columns: 1fr; gap: 0; }
  .toc { display: none; }
  .featured .cover { min-height: 220px; }
}
@media (max-width: 600px) {
  .grid, .tracks { grid-template-columns: 1fr; }
  .trust .wrap { grid-template-columns: 1fr; }
  .trust div + div { padding-left: 0; border-left: 0; border-top: 1px solid var(--line); }
  .post-cover .cover { aspect-ratio: 16/9; }
  .specimen dl { grid-template-columns: repeat(3, minmax(0,1fr)); }
}
@media (prefers-reduced-motion: reduce) { html { scroll-behavior: auto; } .card, .btn { transition: none; } }

/* ---------- about: lab services ---------- */
.lab-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 14px; }
.lab-grid > div { background: var(--surface); border: 1px solid var(--line); border-radius: 16px; padding: 18px 20px; display: flex; flex-direction: column; gap: 6px; min-width: 0; }
.lab-grid strong { font: 500 1.3rem/1.2 var(--f-display); }
.lab-grid p { margin: 0; font-size: .93rem; color: var(--muted); }
.lab-grid .eyebrow { color: var(--gold); }
@media (max-width: 600px) { .lab-grid { grid-template-columns: 1fr; } }

/* ---------- laboratório: serviços, CTA, ilustração ---------- */
.nav-cta { background: var(--ink) !important; color: var(--paper) !important; }
.lab-band { background: var(--surface); border-bottom: 1px solid var(--line); }
.lab-band-head { display: flex; flex-wrap: wrap; justify-content: space-between; align-items: end; gap: 20px; margin-bottom: 28px; }
.lab-band-head > div { max-width: 62ch; min-width: 0; }
.lab-band-head h2 { font-size: clamp(1.8rem, 3.4vw, 2.6rem); font-weight: 500; }
.lab-band-head p { color: var(--muted); margin: 12px 0 0; }
.lab-services { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 14px; }
.lab-services a { text-decoration: none; border: 1px solid var(--line); border-radius: 16px; padding: 18px; display: flex; flex-direction: column; gap: 6px; background: var(--paper); transition: transform .2s ease; }
.lab-services a:hover { transform: translateY(-2px); }
.lab-services strong { font: 500 1.25rem/1.2 var(--f-display); }
.lab-services p { margin: 0; font-size: .9rem; color: var(--muted); }
.lab-services .eyebrow, .svc .eyebrow { color: var(--gold); }
.lab-cta { margin-top: 48px; display: flex; flex-wrap: wrap; align-items: center; justify-content: space-between; gap: 18px; background: var(--ink); color: var(--paper); border-radius: 18px; padding: 24px; }
.lab-cta div { max-width: 46ch; min-width: 0; display: flex; flex-direction: column; gap: 6px; }
.lab-cta .eyebrow { color: var(--gold); }
.lab-cta strong { font: 500 1.2rem/1.35 var(--f-display); }
.lab-cta p { margin: 0 !important; font-size: .9rem; color: color-mix(in srgb, var(--paper) 70%, transparent) !important; }
.lab-cta .btn { background: var(--gold); border-color: var(--gold); color: #1A1407; }
.lab-hero { padding-block: clamp(40px, 6vw, 80px) 24px; }
.lab-hero-grid { display: grid; grid-template-columns: 1fr 1.1fr; gap: clamp(24px, 4vw, 56px); align-items: center; }
.lab-hero h1 { font-size: clamp(2.4rem, 5.4vw, 4.4rem); font-weight: 500; letter-spacing: -.02em; }
.lab-hero h1 em { color: var(--gold); }
.lab-hero .lede { font-size: clamp(1.05rem, 1.5vw, 1.2rem); color: var(--muted); margin: 20px 0 0; max-width: 52ch; }
.official { margin: 22px 0 0; font-weight: 600; display: flex; flex-wrap: wrap; gap: 10px; align-items: center; }
.official span { font: 500 .68rem/1 var(--f-mono); letter-spacing: .12em; text-transform: uppercase; color: var(--paper); background: var(--gold); padding: 6px 9px; border-radius: 6px; }
.icsi-figure { margin: 0; min-width: 0; }
.icsi-art { display: block; width: 100%; height: auto; border-radius: 22px; box-shadow: var(--shadow); }
.icsi-figure figcaption { font-size: .82rem; color: var(--muted); margin-top: 10px; }
.svc-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 18px; }
.svc { background: var(--surface); border: 1px solid var(--line); border-radius: 18px; padding: 24px; scroll-margin-top: 90px; display: flex; flex-direction: column; gap: 10px; }
.svc h3 { font-size: 1.6rem; font-weight: 500; }
.svc p { margin: 0; color: color-mix(in srgb, var(--ink) 85%, var(--paper)); }
.svc ul { margin: 0; padding-left: 1.2em; color: var(--muted); font-size: .93rem; }
.process { list-style: none; padding: 0; margin: 0; display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 14px; counter-reset: step; }
.process li { counter-increment: step; border-top: 2px solid var(--gold); padding-top: 14px; display: flex; flex-direction: column; gap: 6px; }
.process li::before { content: "0" counter(step); font: 500 .75rem/1 var(--f-mono); color: var(--gold); letter-spacing: .1em; }
.process strong { font: 500 1.15rem/1.25 var(--f-display); }
.process span { color: var(--muted); font-size: .92rem; }
.faq { display: grid; gap: 10px; max-width: 860px; }
.faq details { background: var(--surface); border: 1px solid var(--line); border-radius: 14px; padding: 16px 20px; }
.faq summary { cursor: pointer; font-weight: 600; }
.faq p { margin: 10px 0 0; color: var(--muted); }
.contact-box { display: flex; flex-direction: column; gap: 10px; min-width: 0; }
.contact-mail { font: 500 clamp(1.2rem, 2.4vw, 1.7rem)/1.2 var(--f-display); overflow-wrap: anywhere; user-select: all; }
.contact-box > span:not(.eyebrow) { color: color-mix(in srgb, var(--paper) 70%, transparent); font-size: .9rem; }
.contact-box .btn { align-self: flex-start; background: var(--gold); border-color: var(--gold); color: #1A1407; }
@media (max-width: 960px) {
  .lab-services { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .lab-hero-grid, .svc-grid { grid-template-columns: 1fr; }
  .process { grid-template-columns: repeat(2, minmax(0, 1fr)); }
}
@media (max-width: 600px) { .lab-services, .process { grid-template-columns: 1fr; } .nav-cta { display: none; } }

/* ---------- quadro rosa (alerta / dados de risco) ---------- */
:root { --pink-bg: #FCEAF1; --pink-line: #EDB3C8; --pink-ink: #A3285F; }
@media (prefers-color-scheme: dark) { :root:not([data-theme="light"]) { --pink-bg: #33141F; --pink-line: #6E2D47; --pink-ink: #F497BC; } }
:root[data-theme="dark"] { --pink-bg: #33141F; --pink-line: #6E2D47; --pink-ink: #F497BC; }
.callout.alerta { --cat: var(--pink-ink); background: var(--pink-bg); border: 1px solid var(--pink-line); border-left: 4px solid var(--pink-ink); }
.callout.alerta > * + * { margin-top: 1em; }
.callout.alerta .table { background: var(--surface); border-color: var(--pink-line); }
.callout.alerta strong { color: var(--ink); }
.callout.alerta td strong { color: var(--pink-ink); }